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Título: | S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis |
Autor: | Martín-Duce, Antonio; Ortiz, Pablo; Cabrero, Carmen; Mato, José M. | Fecha de publicación: | 1988 | Editor: | Wiley-Blackwell | Citación: | Hepatology 8(1): 65-68 (1988) | Resumen: | We have measured the activity S-adenosyl-L-methionine synthetase in liver biopsies from a group of controls (n = 17) and in 26 cirrhotics (12 alcoholic and 14 posthepatitic). The activity of this enzyme was markedly reduced in the group of cirrhotics (285 ± 32 pmoles per min per mg protein) when compared with that observed in controls (505 ± 37 pmoles per min per mg protein). No differences in S-adenosyl-L-methionine synthetase was observed between both groups of cirrhotics. Similarly, a marked reduction in the activity phospholipid methyltransferase was also observed in liver biopsies from the same group of cirrhotics (105 ± 12 pmoles per min per mg protein) when compared with the control subjects (241 ± 13 pmoles per min per mg protein). Again, no difference in the activity of this enzyme was observed between both groups of cirrhotics. These results indicated a marked deficiency in the metabolism of S-adenosyl-L-methionine in cirrhosis. | URI: | http://hdl.handle.net/10261/78723 | DOI: | 10.1002/hep.1840080113 | Identificadores: | doi: 10.1002/hep.1840080113 issn: 0270-9139 e-issn: 1527-3350 |
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