English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/78586
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Sulfide as a signaling molecule in autophagy

AuthorsGotor, Cecilia ; García, Irene ; Crespo, José L. ; Romero, Luis C.
KeywordsArabidopsis
ATG8 lipidation
Carbon starvation
Cysteine desulfhydrase
Cytosolic sulfide
Senescence
Issue DateApr-2013
PublisherLandes Bioscience
CitationAutophagy 9 (4): 609–611 (2013)
AbstractHydrogen sulfide is already recognized as an important signaling molecule in mammalian systems, and emerging data suggest that H2S is a signaling molecule just as important as nitric oxide (NO) and H2O2 in plants. Although sulfide is generated in chloroplasts and mitochondria, it is present predominantly in the charged HS- form due to the basic pH inside both organelles, thus requiring an active transporter, which is yet to be identified, to be released. In Arabidopsis, we found that the cytosolic L-cysteine desulfhydrase DES1 is involved in the degradation of cysteine, and therefore responsible for the generation of H2S in this cellular compartment. DES1 deficiency leads to the induction of autophagy. Moreover, we have demonstrated that sulfide in particular exerts a general effect on autophagy through negative regulation, in a way unrelated to nutrient deficiency. The mechanisms of H2S action and its molecular targets are largely unknown, although in animal systems, protein Ssulfhydration has been proposed as a mechanism for sulfide-mediated signaling.
Description3 Páginas, 1 figura
Publisher version (URL)http://dx.doi.org/10.4161/auto.23460
URIhttp://hdl.handle.net/10261/78586
DOI10.4161/auto.23460
ISSN1554-8627
Appears in Collections:(IBVF) Artículos
Files in This Item:
File Description SizeFormat 
Autophagy 9 (4) 2013.docx106,67 kBMicrosoft Word XMLView/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.