Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/77872
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Guerrero, Lucia | - |
dc.contributor.author | Marco-Ferreres, Raquel | - |
dc.contributor.author | Serrano, Antonio L. | - |
dc.contributor.author | Arredondo, Juan J. | - |
dc.contributor.author | Cervera, Margarita | - |
dc.date.accessioned | 2013-06-10T10:49:07Z | - |
dc.date.available | 2013-06-10T10:49:07Z | - |
dc.date.issued | 2010 | - |
dc.identifier | doi: 10.1016/j.ydbio.2009.10.006 | - |
dc.identifier | issn: 0012-1606 | - |
dc.identifier.citation | Developmental Biology 337(1): 16-28 (2010) | - |
dc.identifier.uri | http://hdl.handle.net/10261/77872 | - |
dc.description.abstract | Although tight quantitative control of gene expression is required to ensure that organs and tissues function correctly, the transcriptional mechanisms underlying this process still remain poorly understood. Here, we describe novel and evolutionary conserved secondary enhancers that are needed for the regulation of the expression of Troponin I genes. Secondary enhancers are silent when tested individually in electroporated muscles but interact with the primary enhancers and are required to precisely control the appropriate timing, the tissue and fibre specificity, and the quantitative expression of these genes during muscle differentiation. Synergism is completely dependent of the fully conserved MEF2 site present on the primary enhancers core of skeletal muscle Troponin I genes. Thus, while each of these paired enhancers has a different function, the concerted action of both is crucial to recapitulate endogenous gene expression. Through comparative genomics, we predict that this mechanism has also arisen in other mammalian muscle genes. Our results reveal the existence of a novel mechanism, conserved from flies to mammals, to fine-tune gene expression in each muscle and probably other tissues. | - |
dc.description.sponsorship | This research was supported by grants BFU2004-05384, BFU2007-61711BMC from the DGICYT (Spanish Ministry of Education, Culture and Sports), FIS-PS09/01267, Marato-TV3 and by Fundación Mutua Madrileña. R. M-F. was supported by the Fundación Mutua Madrileña. L.G. is a Juan de la Cierva (MEC) postdoctoral fellow, J.J.A. is Ramón y Cajal (MEC) investigator, A.L.S. is a recipient of a contract from the “I3 Program” (MICINN). | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.title | Secondary enhancers synergise with primary enhancers to guarantee fine-tuned muscle gene expression | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.ydbio.2009.10.006 | - |
dc.date.updated | 2013-06-10T10:49:07Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
22
checked on 10-abr-2024
WEB OF SCIENCETM
Citations
20
checked on 20-feb-2024
Page view(s)
284
checked on 18-abr-2024
Download(s)
100
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.