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Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)

AuthorsSeifert, K.; Matu, S.; Pérez-Victoria, F. J.; Castanys, Santiago; Gamarro, Francisco; Croft, S. L.
Issue Date2003
CitationInternational Journal of Antimicrobial Agents 22: 380- 387 (2003)
AbstractLeishmania donovani promastigote lines resistant to hexadecylphosphocholine (HePC, miltefosine) at 2.5, 5.0, 10.0, 20.0 and 40.0 μM were developed in vitro by continuous step-wise drug pressure. The 40 μM line was 15 times more resistant to HePC than the wild-type clone and showed cross-resistance to the ether lipid ET-18-OCH3 (edelfosine) but not to the standard anti-leishmanial drugs. Resistance was stable up to 12 weeks in drug-free culture medium. No amplification of specific genes, including the multidrug resistance P-glycoprotein gene, could be detected in the resistant parasites. © 2003 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Identifiersdoi: 10.1016/S0924-8579(03)00125-0
issn: 0924-8579
Appears in Collections:(IPBLN) Artículos
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