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dc.contributor.authorSeifert, K.-
dc.contributor.authorMatu, S.-
dc.contributor.authorPérez-Victoria, F. J.-
dc.contributor.authorCastanys, Santiago-
dc.contributor.authorGamarro, Francisco-
dc.contributor.authorCroft, S. L.-
dc.date.accessioned2013-06-07T10:59:28Z-
dc.date.available2013-06-07T10:59:28Z-
dc.date.issued2003-
dc.identifierdoi: 10.1016/S0924-8579(03)00125-0-
dc.identifierissn: 0924-8579-
dc.identifier.citationInternational Journal of Antimicrobial Agents 22: 380- 387 (2003)-
dc.identifier.urihttp://hdl.handle.net/10261/77813-
dc.description.abstractLeishmania donovani promastigote lines resistant to hexadecylphosphocholine (HePC, miltefosine) at 2.5, 5.0, 10.0, 20.0 and 40.0 μM were developed in vitro by continuous step-wise drug pressure. The 40 μM line was 15 times more resistant to HePC than the wild-type clone and showed cross-resistance to the ether lipid ET-18-OCH3 (edelfosine) but not to the standard anti-leishmanial drugs. Resistance was stable up to 12 weeks in drug-free culture medium. No amplification of specific genes, including the multidrug resistance P-glycoprotein gene, could be detected in the resistant parasites. © 2003 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.-
dc.language.isoeng-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.titleCharacterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)-
dc.typeartículo-
dc.identifier.doi10.1016/S0924-8579(03)00125-0-
dc.date.updated2013-06-07T10:59:29Z-
dc.description.versionPeer Reviewed-
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