Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/77579
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo |
Autor: | Morales-García, José A. CSIC ORCID; Luna Medina, Rosario de CSIC; Alfaro-Cervello, Clara; Cortés-Canteli, Marta CSIC ORCID; Santos, Ángel; García-Verdugo, José Manuel; Pérez Castillo, Ana CSIC ORCID | Fecha de publicación: | 2011 | Editor: | Wiley-Blackwell | Citación: | Glia 59(2): 293-307 (2011) | Resumen: | Peroxisome proliferator-activated receptor gamma (PPARγ) belongs to a family of ligand-activated nuclear receptors and its ligands are known to control many physiological and pathological situations. Its role in the central nervous system has been under intense analysis during the last years. Here we show a novel function for PPARγ in controlling stem cell expansion in the adult mammalian brain. Adult rats treated with pioglitazone, a specific ligand of PPARγ, had elevated numbers of proliferating progenitor cells in the subventricular zone and the rostral migratory stream. Electron microscopy analysis also showed important changes in the subventricular zone ultrastructure of pioglitazone-treated animals including an increased number of migratory cell chains. These results were further confirmed in vitro. Neurosphere assays revealed significant increases in the number of neurosphere forming cells from pioglitazone- and rosiglitazone (two specific ligands of PPARγ receptor)-treated cultures that exhibited enhanced capacity for cell migration and differentiation. The effects of pioglitazone were blocked by the PPARγ receptor antagonists GW9662 and T0070907, suggesting that its effects are mediated by a mechanism dependent on PPARγ activation. These results indicate for the first time that activation of PPARγ receptor directly regulates proliferation, differentiation, and migration of neural stem cells in vivo. © 2010 Wiley-Liss, Inc. | Versión del editor: | http://dx.doi.org/10.1002/glia.21101 | URI: | http://hdl.handle.net/10261/77579 | DOI: | 10.1002/glia.21101 | Identificadores: | doi: 10.1002/glia.21101 issn: 0894-1491 e-issn: 1098-1136 |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Peroxisome proliferator-activated.pdf | 2,48 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
31
checked on 17-mar-2024
SCOPUSTM
Citations
65
checked on 28-mar-2024
WEB OF SCIENCETM
Citations
67
checked on 28-feb-2024
Page view(s)
438
checked on 28-mar-2024
Download(s)
470
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.