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http://hdl.handle.net/10261/77395
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dc.contributor.author | Romero-Pérez, Laura | - |
dc.contributor.author | Castilla, María Ángeles | - |
dc.contributor.author | López-García, María Ángeles | - |
dc.contributor.author | Díaz-Martín, J. | - |
dc.contributor.author | Biscuola, Michele | - |
dc.contributor.author | Ramiro-Fuentes, Susana | - |
dc.contributor.author | Oliva, Esther | - |
dc.contributor.author | Matías-Guiu, Xavier | - |
dc.contributor.author | Cano, Amparo | - |
dc.contributor.author | Moreno-Bueno, Gema | - |
dc.contributor.author | Palacios Calvo, José | - |
dc.date.accessioned | 2013-06-03T12:42:49Z | - |
dc.date.available | 2013-06-03T12:42:49Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier | issn: 0046-8177 | - |
dc.identifier | e-issn: 1532-8392 | - |
dc.identifier.citation | Human Pathology 44(2): 244-254 (2013) | - |
dc.identifier.uri | http://hdl.handle.net/10261/77395 | - |
dc.description.abstract | The molecular events implicated in the development of endometrial carcinosarcoma remain poorly understood. Using complementary DNA microarrays, we analyzed a group of 15 endometrial carcinosarcomas and compared their gene expression profiles with those obtained from a group of 23 endometrioid endometrial carcinomas. We demonstrated changes in the expression of genes modulating processes such as the epithelial to mesenchymal transition, muscle differentiation, the expression of cancer/testis antigens, and immune response in endometrial carcinosarcomas. The high mobility group AT-hook 2 gene is an embryonic nuclear factor that mediates epithelial to mesenchymal transition in various tumor models, and it was among the genes overexpressed in endometrial carcinosarcomas. High mobility group AT-hook 2 overexpression was confirmed in 54% of endometrial carcinosarcomas by quantitative real time-polymerase chain reaction and immunohistochemistry. Moreover, we found a significant inverse correlation between the expression of high mobility group AT-hook 2 and let-7b, a member of the let-7 family of microRNAs that represses high mobility group AT-hook 2 expression. These changes were also associated with overexpression of Lin28B, a suppressor of microRNA biogenesis that is implicated in cancer progression and metastasis. Finally, high mobility group AT-hook 2 overexpression, which was detected in less than 3% of endometrioid endometrial carcinomas, was observed in many nonendometrioid carcinomas (46% of 28 samples). This pattern of expression, restricted to nonendometrioid carcinomas and endometrial carcinosarcomas, reflects a role for high mobility group AT-hook 2 in endometrial carcinogenesis that is associated with aggressive phenotypes and points to its potential use as a marker to distinguish between endometrioid and nonendometrioid tumors. © 2013 Elsevier Inc. | - |
dc.description.sponsorship | This work was supported by grants from the Instituto de Salud Carlos III (ISCIII; grant nos. PI07/90324 and PI080971) and the Ministerio de Ciencia e Innovación (MCINN), cofinanced by the European Development Regional Fund “A way to achieve Europe” EDRF (grant no. RD06/0020/0013); the Junta de Andalucía (Consejería de Salud, grant nos. PI-0384/2007 and PI0581/2009) and the Consejería de Innovación (Proyecto de Excelencia, grant no. P07-CVI-03100) to J. Pa.; grants FISPI10/00922, 2009SGR794, and RD06/0020/134 to X. M-G. and RD/0020/15 to J. Pr.; and by a grant from the Asociación Española Contra el Cáncer, Red de Grupos estables en Oncología (AECC-2011) to X. M-G., J. Pr., and G. M-B. L. R-P. is a PhD student and a recipient of a PFIS fellowship (grant no. F109/00193). M. A. C. and J. D. are PhD researchers funded by the ISCIII (grant no. RD06/0020/0013) and the Consejería de Salud de la Junta de Andalucía (PI0581/2009), respectively. M. B. is a researcher funded by the ISCIII-Red de Biobancos RD09/0076/00085. S. R-F. works as a laboratory technician supported by the ISCIII (PI080971). Tumor samples were obtained with the support of Xarxa Catalana de Bancs de Tumors, the Tumor Bank Platform of RTICC RD09/0076/00085 and RD09/0076/00059. | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.title | Molecular events in endometrial carcinosarcomas and the role of high mobility group AT-hook 2 in endometrial carcinogenesis | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.humpath.2012.05.013 | - |
dc.relation.publisherversion | http://doi.org/10.1016/j.humpath.2012.05.013 | - |
dc.date.updated | 2013-06-03T12:42:49Z | - |
dc.description.version | Peer Reviewed | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Asociación Española Contra el Cáncer | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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