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dc.contributor.authorGallardo, M. Esther-
dc.contributor.authorGarcía-Pavía, Pablo-
dc.contributor.authorChamorro-Garcia, Raquel-
dc.contributor.authorDomingo, Verónica-
dc.contributor.authorGaresse, Rafael-
dc.contributor.authorBornstein, Belén-
dc.identifierdoi: 10.1093/eurheartj/ehr280-
dc.identifierissn: 0195-668X-
dc.identifiere-issn: 1522-9645-
dc.identifier.citationEuropean Heart Journal 33(3): 346-353 (2012)-
dc.description.abstract[Aims]: Mitochondrial haplogroups are known to influence individual predisposition to a wide spectrum of metabolic and degenerative diseases, including ischaemic cardiovascular diseases. We have examined the influence of the mitochondrial DNA (mtDNA) background on the development of human end-stage heart failure (HF) in patients undergoing heart transplantation. The influence of mtDNA haplogroups on the incidence of transplant-related complications, mainly cardiac allograft vasculopathy (CAV), and on post-transplant survival was also studied. [Methods and results]: The most common mitochondrial haplogroups in European populations were genotyped in 450 heart transplant recipients, 248 heart transplant donors, and 206 healthy controls. Mitochondrial haplogroups were determined by PCR amplification of short mtDNA fragments, followed by restriction fragment length polymorphism analysis. After adjustment for age and sex the frequency of haplogroup H was significantly higher in heart transplant recipients than in controls [OR: 1.86 (95 confidence intervals, CI: 1.272.74), P=0.014], and in heart donors [OR: 1.47 (95 CI: 0.992.19), P=0.032]. Likewise, haplogroup Uk was found significantly more frequently among CAV patients than in non-CAV heart allograft recipients [OR: 4.1 (95 CI: 1.51-11.42), P=0.042]. Finally, heart donor haplogroups had no influence on the morbidity or mortality after heart transplantation. [Conclusions]: Mitochondrial haplogroups behave like risk factors for the progress to end-stage HF in a Spanish cardiac transplant population. Mitochondrial DNA variants may have some influence on the appearance of cardiac transplant complications. © 2011 The Author.-
dc.description.sponsorshipThis work was supported by the Instituto de Salud Carlos III (ISCIII) (grant number PI 06/0205 to B.B. and PI 07/0167 to R.G.); Comunidad de Madrid (grant number GEN-0269/2006 to R.G.); Ministerio de Ciencia e Innovación (SAF2010-22153-C03-03 to C.V.); and Sociedad Española de Cardiología (2008 to M.G.B.). M.E.G. is a Senior Fellow and receives grant support from the Center for Biomedical Research on Rares Diseases (CIBERER); M.E.V. is a Junior Fellow and receives grant support from REDINSCOR, a clinical and scientific research network on heart failure supported by ISCIII.-
dc.publisherOxford University Press-
dc.titleMitochondrial haplogroups associated with end-stage heart failure and coronary allograft vasculopathy in heart transplant patients-
dc.description.versionPeer Reviewed-
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