Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/77349COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Peinado, Héctor | - |
| dc.contributor.author | Moreno-Bueno, Gema | - |
| dc.contributor.author | Hergueta-Redondo, Marta | - |
| dc.contributor.author | Bromberg, Jacqueline | - |
| dc.contributor.author | Lyden, David | - |
| dc.date.accessioned | 2013-06-03T09:26:36Z | - |
| dc.date.available | 2013-06-03T09:26:36Z | - |
| dc.date.issued | 2012 | - |
| dc.identifier | doi: 10.1038/nm.2753 | - |
| dc.identifier | issn: 1078-8956 | - |
| dc.identifier | e-issn: 1546-170X | - |
| dc.identifier.citation | Nature Medicine 18(6): 883-891 (2012) | - |
| dc.identifier.uri | http://hdl.handle.net/10261/77349 | - |
| dc.description | El pdf del artículo es el manuscrito de autor.-- et al. | - |
| dc.description.abstract | Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and human subjects. Exosomes from highly metastatic melanomas increased the metastatic behavior of primary tumors by permanently 'educating' bone marrow progenitors through the receptor tyrosine kinase MET. Melanoma-derived exosomes also induced vascular leakiness at pre-metastatic sites and reprogrammed bone marrow progenitors toward a pro-vasculogenic phenotype that was positive for c-Kit, the receptor tyrosine kinase Tie2 and Met. Reducing Met expression in exosomes diminished the pro-metastatic behavior of bone marrow cells. Notably, MET expression was elevated in circulating CD45(-)C-KIT(low/+)TIE2(+) bone marrow progenitors from individuals with metastatic melanoma. RAB1A, RAB5B, RAB7 and RAB27A, regulators of membrane trafficking and exosome formation, were highly expressed in melanoma cells. Rab27A RNA interference decreased exosome production, preventing bone marrow education and reducing, tumor growth and metastasis. In addition, we identified an exosome-specific melanoma signature with prognostic and therapeutic potential comprised of TYRP2, VLA-4, HSP70, an HSP90 isoform and the MET oncoprotein. Our data show that exosome production, transfer and education of bone marrow cells supports tumor growth and metastasis, has prognostic value and offers promise for new therapeutic directions in the metastatic process. | - |
| dc.language.iso | eng | - |
| dc.publisher | Nature Publishing Group | - |
| dc.rights | openAccess | - |
| dc.title | Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET | - |
| dc.type | artículo | - |
| dc.identifier.doi | 10.1038/nm.2753 | - |
| dc.relation.publisherversion | http://dx.doi.org/10.1038/nm.2753 | - |
| dc.date.updated | 2013-06-03T09:26:36Z | - |
| dc.description.version | Peer Reviewed | - |
| dc.identifier.pmid | 22635005 | - |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
| item.openairetype | artículo | - |
| item.grantfulltext | open | - |
| item.cerifentitytype | Publications | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.fulltext | With Fulltext | - |
| item.languageiso639-1 | en | - |
| Aparece en las colecciones: | (IIBM) Artículos | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Melanoma exosomes.pdf | 3,86 MB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
1.805
checked on 24-abr-2024
SCOPUSTM
Citations
2.877
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
2.698
checked on 24-feb-2024
Page view(s)
565
checked on 23-abr-2024
Download(s)
505
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.