Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/76937
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | FOXO1 controls thyroid cell proliferation in response to TSH and IGF-I and is involved in thyroid tumorigenesis |
Autor: | Zaballos, Miguel A. CSIC ORCID; Santisteban, Pilar CSIC ORCID | Fecha de publicación: | 2013 | Editor: | Endocrine Society | Citación: | Molecular Endocrinology 27(1): 50-62 (2013) | Resumen: | TSH and insulin/IGF-I synergistically induce the proliferation of thyroid cells mainly through the cAMP and phosphatidylinositol 3-kinase (PI3K) pathways. However, the events involved in this cooperative induction remain unknown, and molecules that are potentially controlled by both TSH and IGF-I are interesting candidates as integrators of both stimuli. The finding that the PI3K pathway is frequently activated in thyroid malignancies has attracted attention to this pathway in the thyroid field. One of the targets of PI3K is Forkhead box O (FoxO)-1, a widely expressed transcription factor involved in a variety of cellular processes such as differentiation, proliferation, and apoptosis. Here we show that FoxO1 is highly expressed in differentiated rat thyroid cells and human thyroid tissue compared with human thyroid tumor-derived cells and surgically removed thyroid tumors, in which its expression is reduced. In differentiated cells, TSH/cAMP treatment decreases FoxO1 mRNA and protein levels through proteasome activation, whereas both TSH and IGF-I control FoxO1 localization by promoting a rapid exclusion from the nucleus in an Akt-dependent manner. FoxO1 can control p27KIP1 expression in differentiated and tumor cells of the thyroid. Furthermore, FoxO1 reexpression in tumor cells promotes a decrease in their proliferation rate, whereas FoxO1 interference in differentiated cells increases their proliferation. These data point to an important role of FoxO1 in mediating the effects of TSH and IGF-I on thyroid cell proliferation and provide a link between loss of FoxO1 expression and the uncontrolled proliferation of thyroid tumor cells. © 2013 by The Endocrine Society. | Versión del editor: | http://dx.doi.org/10.1210/me.2012-1032 | URI: | http://hdl.handle.net/10261/76937 | DOI: | 10.1210/me.2012-1032 | Identificadores: | doi: 10.1210/me.2012-1032 issn: 0888-8809 e-issn: 1944-9917 |
Aparece en las colecciones: | (IIBM) Artículos |
Mostrar el registro completo
CORE Recommender
PubMed Central
Citations
21
checked on 20-abr-2024
SCOPUSTM
Citations
42
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
41
checked on 24-feb-2024
Page view(s)
322
checked on 23-abr-2024
Download(s)
99
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.