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http://hdl.handle.net/10261/76861
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Castanys-Muñoz, E. | - |
dc.contributor.author | Pérez-Victoria, J. M. | - |
dc.contributor.author | Gamarro, Francisco | - |
dc.contributor.author | Castanys, Santiago | - |
dc.date.accessioned | 2013-05-27T11:02:56Z | - |
dc.date.available | 2013-05-27T11:02:56Z | - |
dc.date.issued | 2008 | - |
dc.identifier | doi: 10.1128/AAC.00587-08 | - |
dc.identifier | issn: 0066-4804 | - |
dc.identifier.citation | Antimicrobial Agents and Chemotherapy 52: 3573- 3579 (2008) | - |
dc.identifier.uri | http://hdl.handle.net/10261/76861 | - |
dc.description.abstract | Leishmaniasis treatment is hampered by the increased appearance of treatment failure. ATP-binding cassette (ABC) transporters are usually involved in drug resistance both in tumor cells and in microorganisms. Here we report the characterization of an ABCG-like transporter, LiABCG6, localized mainly at the plasma membrane in Leishmania protozoan parasites. When overexpressed, this half-transporter confers significant resistance to the leishmanicidal agents miltefosine and sitamaquine. This resistance phenotype is mediated by a reduction in intracellular drug accumulation. LiABCG6 also reduces the accumulation of short-chain fluorescent phospholipid analogues of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine. As a whole, these results suggest that LiABCG6 could be implicated in phospholipid trafficking and drug resistance. Copyright © 2008, American Society for Microbiology. All Rights Reserved. | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Microbiology | - |
dc.rights | closedAccess | - |
dc.title | Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1128/AAC.00587-08 | - |
dc.date.updated | 2013-05-27T11:02:56Z | - |
dc.description.version | Peer Reviewed | - |
dc.identifier.pmid | 18644961 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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