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dc.contributor.authorLavado Autric, Rosalía-
dc.contributor.authorCalvo, Rosa M.-
dc.contributor.authorMartínez de Mena, Raquel-
dc.contributor.authorMorreale de Escobar, Gabriella-
dc.contributor.authorObregón, María Jesús-
dc.identifierdoi: 10.1210/en.2012-1727-
dc.identifierissn: 0013-7227-
dc.identifiere-issn: 1945-7170-
dc.identifier.citationEndocrinology 154(1): 529-536 (2013)-
dc.description.abstractSevere iodine deficiency is characterized by goiter, preferential synthesis, and secretion of T3 in thyroids, hypothyroxinemia in plasma and tissues, normal or low plasma T3, and slightly increased plasma TSH. We studied changes in deiodinase activities and mRNA in several tissues of rats maintained on low-iodine diets (LIDs) or LIDs supplemented with iodine (LID+I). T4 and T3 concentrations decreased in plasma, tissues, and thyroids of LID rats, and T4 decreased more than T3 (50%). The highest type 1 iodothyronine deiodinase (D1) activities were found in the thyroid, kidney, and the liver; pituitary, lung, and ovary had lower D1 activities; but the lowest levels were found in the heart and skeletal muscle. D1 activity decreased in all tissues of LID rats (10-40% of LID+I rats), except for ovary and thyroids, which D1 activity increased 2.5-fold. Maximal type 2 iodothyronine deiodinase (D2) activities were found in thyroid, brown adipose tissue, and pituitary, increasing 6.5-fold in thyroids of LID rats and about 20-fold in the whole gland. D2 always increased in response to LID, and maximal increases were found in the cerebral cortex (19-fold), thyroid, brown adipose tissue, and pituitary (6-fold). Lower D2 activities were found in the ovary, heart, and adrenal gland, which increased in LID. Type 3 iodothyronine deiodinase activity was undetectable. Thyroidal Dio1 and Dio2 mRNA increased in the LID rats, and Dio1 decreased in the lung, with no changes in mRNA expression in other tissues. Our data indicate that LID induces changes in deiodinase activities, especially in the thyroid, to counteract the low T 4 synthesis and secretion, contributing to maintain the local T 3 concentrations in the tissues with D2 activity. Copyright © 2013 by The Endocrine Society.-
dc.description.sponsorshipThis work was supported by Research Grants CAM 08.5/0059.1 /2000 (to G.M.d.E.) and S2010-BMD-2423 from the Comunidad de Madrid (Spain) and Research Grants SAF2001-2243, SAF2006-01319, and SAF2009-09364 from Ministerio de Education y Ciencia (MEC) and Ministerio de Investigacion Ciencia e Innovacion (MICINN) (to M.-J.O.).-
dc.publisherEndocrine Society-
dc.titleDeiodinase activities in thyroids and tissues of iodine-deficient female rats-
dc.description.versionPeer Reviewed-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
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