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Título:	"Louping ill" in goat in northern Spain: more than a forgotten disease
Autor:	Balseiro, Ana CSIC ORCID ; Royo, Luis J.; Copano, María Francisca; Höfle, Ursula CSIC ORCID; García Marín, Juan Francisco CSIC
Fecha de publicación:	2012
Citación:	Joint Meeting of 30th ESVP-ECVP and 24th SEAPV (2012)
Resumen:	[Introduction]: Louping ill (LI) is a zoonotic disease caused by a neurotropic singlestrand RNA virus that has been classified into the Flavivirus genus. We report the case of a “Bermeya” goat herd of 70 animals from Asturias, suspected of being infected with a tick-borne encephalitis virus. [Materials and Methods]: Eighteen goats died showing neurological clinical signs. Necropsy was performed in two adult goats. Samples of brain were taken for further histopathological and molecular genetic (RT-PCR and sequencing) studies. In order to confirm the importance of the infection, a serological survey (ELISA) was performed in 178 goats belonging to seven herds geographically close to the affected one. [Results]: The cerebellum showed necrosis of Purkinje cells and neurons. A mild meningeal infiltration with widespread lymphocytic perivascular cuffs, phenomena of neurophagia and gliosis was observed mainly in the hypothalamus region and midbrain, being more severe in the medulla oblongata and cervical spinal cord. Molecular genetic studies identified the virus as a LI strain not described so far. Histopathological lesions together with molecular studies allowed a complete diagnosis: tick-borne encephalitis caused by a new strain of LI virus. The serological survey confirmed the infection in 5.06% of the animals studied. [Discussion & Conclusions]: These findings underline the necessity to implement a specific surveillance plan in Northern Spain focused on ticks, wildlife species and livestock.
Descripción:	Resumen del trabajo presentado al Joint Meeting of 30th Meeting of the European Society of Veterinary Pathology-Annual Meeting of the European College of Veterinary Pathology and 24th Annual Meeting of the Spanish Society of Veterinary Pathology, celebrado en León (España) del 5 al 8 de septiembre de 2012.-- et al.
URI:	http://hdl.handle.net/10261/75813
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