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Título: | Role of endothelin in the cardiovascular system |
Autor: | Rodríguez-Pascual, Fernando CSIC ORCID; Busnadiego, Óscar CSIC; Lagares, David CSIC; Lamas Peláez, Santiago CSIC ORCID | Palabras clave: | Cardiovascular diseases Endothelin Peptide ligands G-protein-coupled receptors |
Fecha de publicación: | 2011 | Editor: | Elsevier | Citación: | Pharmacological Research 63 (6):463-72 (2011) | Resumen: | The endothelin (ET) system consists of three peptide ligands (ET-1, ET-2 and ET-3) and two G-protein-coupled receptors, ET(A) and ET(B). In the cardiovascular system, ETs, particularly ET-1, are expressed in smooth muscle cells, cardiomyocytes, fibroblasts, and notably in vascular endothelial cells. Intense research over the last 10 years has changed the original view of ET-1 as mainly a vasoconstrictor regulating blood pressure, into a biological factor regulating processes such as vascular remodeling, angiogenesis or extracellular matrix synthesis. The advent of specific (and type-selective) ET receptor antagonists has greatly fostered our knowledge of the biological function of ET-1, and has offered a potential therapeutic approach for numerous diseases including hypertension, atherosclerosis or fibrosis. In this article, we review the regulation of the expression of vascular ET-1, as well as the contribution of ET-1 to endothelial, smooth muscle and fibroblast cell function, with particular interest in the role of ET-1 in the development of cardiovascular diseases. | Versión del editor: | http://dx.doi.org/10.1016/j.phrs.2011.01.014 | URI: | http://hdl.handle.net/10261/75156 | DOI: | 10.1016/j.phrs.2011.01.014 | ISSN: | 1043-6618 |
Aparece en las colecciones: | (CBM) Artículos |
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