Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/75150
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Moliné-Velázquez, Verónica | - |
dc.contributor.author | Cuervo, Henar | - |
dc.contributor.author | Vila-del Sol, Virginia | - |
dc.contributor.author | Ortega, María Cristina | - |
dc.contributor.author | Clemente, Diego | - |
dc.contributor.author | Castro Soubriet, Fernando de | - |
dc.date.accessioned | 2013-04-25T17:50:19Z | - |
dc.date.available | 2013-04-25T17:50:19Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Brain Pathology 21(6):678-91 (2011) | es_ES |
dc.identifier.issn | 1015-6305 | - |
dc.identifier.uri | http://hdl.handle.net/10261/75150 | - |
dc.description.abstract | Multiple Sclerosis (MS) is a demyelinating/inflammatory disease of the central nervous system. Relapsing-remitting MS is characterized by a relapsing phase with clinical symptoms and the production of inflammatory cell infiltrates, and a period of remission during which patients recover partially. Myeloid-derived suppressor cells (MDSCs) are immature cells capable of suppressing the inflammatory response through Arginase-I (Arg-I) activity, among other mechanisms. Here, we have identified Arg-I+-MDSCs in the spinal cord during experimental autoimmune encephalomyelitis (EAE), cells that were largely restricted to the demyelinating plaque and that always exhibited the characteristic MDSC surface markers Arg-I/CD11b/Gr-1/M-CSF1R. The presence and density of Arg-I+-cells, and the proportion of apoptotic but not proliferative T cells, were correlated with the EAE time course: peaked in parallel with the clinical score, decreased significantly during the remitting phase and completely disappeared during the chronic phase. Spinal cord-isolated MDSCs of EAE animals augmented the cell death when co-cultured with stimulated control splenic CD3 T cells. These data point to an important role for MDSCs in limiting inflammatory damage in MS, favoring the relative recovery in the remitting phase of the disease. Thus, the MDSC population should be considered as a potential therapeutic target to accelerate the recovery of MS patients. | es_ES |
dc.description.sponsorship | This work was supported by the Ministerio de Ciencia e Innovación-MICINN (SAF2009-07842); Fondo de Investigaciones Sanitarias-FIS (partially funded by F.E.D.E.R.- European Union—“Una manera de hacer Europa”) (RD07-0060-2007); and Gobierno de Castilla-La Mancha (PAI08-0242-3822; ICS06024-00, G-2008-C8; PI2009-26). VMV and MCO are FISCAM fellows (MOV-2009_JI-01 and MOV-2007_JI-20, respectively). DC, VV and FdC are hired by SESCAM. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Demyelination | es_ES |
dc.subject | EAE | es_ES |
dc.subject | Immunomodulation | es_ES |
dc.subject | Lymphocyte | es_ES |
dc.subject | Macrophage | es_ES |
dc.subject | Remyelination | es_ES |
dc.title | Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis. | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1111/j.1750-3639.2011.00495.x | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1111/j.1750-3639.2011.00495.x | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Junta de Comunidades de Castilla-La Mancha | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011698 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
91
checked on 23-mar-2024
WEB OF SCIENCETM
Citations
87
checked on 25-feb-2024
Page view(s)
353
checked on 18-abr-2024
Download(s)
106
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.