Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/7489
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Fluid-dynamical basis of the embryonic development of left right asymmetry in vertebrates |
Autor: | Cartwright, Julyan H. E. CSIC ORCID ; Piro, Oreste CSIC ORCID; Tuval, Idan CSIC ORCID | Palabras clave: | Physics Developmental biology |
Fecha de publicación: | 11-may-2004 | Editor: | National Academy of Sciences (U.S.) | Citación: | Proceedings of the National Academy of Sciences of the USA (PNAS) 101(19): 7234-7239 (2004) | Resumen: | Experimental work in developmental biology has recently shown in mice that fluid flow driven by rotating cilia in the node, a structure present in the early stages of growth of vertebrate embryos, is responsible for determining the normal development of the left--right axis, with the heart on the left of the body, the liver on the right, and so on. The role of physics, in particular of fluid dynamics, in the process, is one of the important questions that remain to be answered. We show with an analysis of the fluid dynamics of the nodal flow in the developing embryo that the leftward flow that has been experimentally observed may be produced by the monocilia driving it being tilted toward the posterior. We propose a model for morphogen transport and mixing in the nodal flow, and discuss how this might initiate the development of left--right asymmetry. | Descripción: | 6 pages, 4 figures.-- PMCID: PMC409902.-- Open Access version available at PMC: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=409902.-- Supplementary material available: Supporting text "Modeling with rotlets" (3 pages). | Versión del editor: | http://dx.doi.org/10.1073/pnas.0402001101 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=409902 |
URI: | http://hdl.handle.net/10261/7489 | DOI: | 10.1073/pnas.0402001101 | ISSN: | 0027-8424 |
Aparece en las colecciones: | (IFISC) Artículos (IACT) Artículos |
Mostrar el registro completo
CORE Recommender
PubMed Central
Citations
54
checked on 05-abr-2024
SCOPUSTM
Citations
163
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
153
checked on 29-feb-2024
Page view(s)
372
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.