English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/7489
Title: Fluid-dynamical basis of the embryonic development of left right asymmetry in vertebrates
Authors: Cartwright, Julyan H. E.; Piro, Oreste; Tuval, Idan
Keywords: Physics
Developmental biology
Issue Date: 11-May-2004
Publisher: National Academy of Sciences (U.S.)
Citation: Proceedings of the National Academy of Sciences of the USA (PNAS) 101(19): 7234-7239 (2004)
Abstract: Experimental work in developmental biology has recently shown in mice that fluid flow driven by rotating cilia in the node, a structure present in the early stages of growth of vertebrate embryos, is responsible for determining the normal development of the left--right axis, with the heart on the left of the body, the liver on the right, and so on. The role of physics, in particular of fluid dynamics, in the process, is one of the important questions that remain to be answered. We show with an analysis of the fluid dynamics of the nodal flow in the developing embryo that the leftward flow that has been experimentally observed may be produced by the monocilia driving it being tilted toward the posterior. We propose a model for morphogen transport and mixing in the nodal flow, and discuss how this might initiate the development of left--right asymmetry.
Description: 6 pages, 4 figures.-- PMCID: PMC409902.-- Open Access version available at PMC: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=409902.-- Supplementary material available: Supporting text "Modeling with rotlets" (3 pages).
Publisher version (URL): http://dx.doi.org/10.1073/pnas.0402001101
URI: http://hdl.handle.net/10261/7489
ISSN: 0027-8424
DOI: 10.1073/pnas.0402001101
Appears in Collections:(IFISC) Artículos
(IACT) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.