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http://hdl.handle.net/10261/74325
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dc.contributor.author | Luczkowiak, Joanna | - |
dc.contributor.author | Sattin, Sara | - |
dc.contributor.author | Sutkeviciute, Ieva | - |
dc.contributor.author | Reina, José J. | - |
dc.contributor.author | Sánchez-Navarro, Macarena | - |
dc.contributor.author | Thépaut, Michel | - |
dc.contributor.author | Martínez-Prats, Lorena | - |
dc.contributor.author | Daghetti, Anna | - |
dc.contributor.author | Fieschi, Franck | - |
dc.contributor.author | Delgado, R. | - |
dc.contributor.author | Bernardi, Anna | - |
dc.contributor.author | Rojo, Francisco Javier | - |
dc.date.accessioned | 2013-04-15T10:51:50Z | - |
dc.date.available | 2013-04-15T10:51:50Z | - |
dc.date.issued | 2011 | - |
dc.identifier | doi: 10.1021/bc20000403 | - |
dc.identifier | issn: 1043-1802 | - |
dc.identifier.citation | Bioconjugate Chemistry 22: 1354- 1365 (2011) | - |
dc.identifier.uri | http://hdl.handle.net/10261/74325 | - |
dc.description.abstract | The development of compounds with strong affinity for the receptor DC-SIGN is a topic of remarkable interest due to the role that this lectin plays in several pathogen infection processes and in the modulation of the immune response. DC-SIGN recognizes mannosylated and fucosylated oligosaccharides in a multivalent manner. Therefore, multivalent carbohydrate systems are required to interact in an efficient manner with this receptor and compete with the natural ligands. We have previously demonstrated that linear pseudodi- and pseudotrisaccharides are adequate ligands for DC-SIGN. In this work, we show that multivalent presentations of these glycomimetics based on polyester dendrons and dendrimers lead to very potent inhibitors (in the nanomolar range) of cell infection by Ebola pseudotyped viral particles by blocking DC-SIGN receptor. Furthermore, SPR model experiments confirm that the described multivalent glycomimetic compounds compete in a very efficient manner with polymannosylated ligands for binding to DC-SIGN. | - |
dc.description.sponsorship | We would like to acknowledge the financial support by the MICINN of Spain CTQ2008-01694, the EU RTN CARMUSYS (PITN-GA-2008-213592), Comune di Milano (Convenzione 55/2008), Sidaction – Ensemble contre le Sida, Fundación Mutua Madrileña (FMM2007-700) and the European FEDER funds. The expression plasmid for the glycoprotein of the Zaire strain of Ebola virus was kindly provided by Dr. A. Sanchez, Centers for Disease Control and Prevention, Atlanta, GA. | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.rights | closedAccess | - |
dc.title | Pseudosaccharide functionalized dendrimers as potent inhibitors of DC-SIGN dependent Ebola Pseudotyped viral infection | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1021/bc20000403 | - |
dc.date.updated | 2013-04-15T10:51:53Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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