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| Título: | Non-targeted metabolomic approach reveals urinary metabolites linked to steroid biosynthesis pathway after ingestion of citrus juice |
Autor: | Medina Escudero, Sonia CSIC ORCID; Ferreres, Federico CSIC ORCID; García-Viguera, Cristina CSIC ORCID; Orduna, Jesús CSIC ORCID ; Savirón, María; Gil-Izquierdo, Ángel CSIC ORCID | Fecha de publicación: | 2013 | Editor: | Elsevier | Citación: | Food Chemistry 136(2): 938-946 (2013) | Resumen: | Citrus juice intake has been highlighted because of its health-promoting effects. LC-MS based metabolomics approaches are applied to obtain a better knowledge on changes in the concentration of metabolites due to its dietary intake and allow a better understanding of involved metabolic pathways. Eight volunteers daily consumed 400 mL of juice for four consecutive days and urine samples were collected before intake and 24 h after each citrus juice intake. Urine samples were analysed by nanoHPLC-q-TOF, followed by principal component analysis (PCA) and Student's t-test (p < 0.05). PCA showed a separation between two groups (before and after citrus juice consumption). This approach allowed the identification of four endocrine compounds (tetrahydroaldosterone-3- glucuronide, cortolone-3-glucuronide, testosterone-glucuronide and 17-hydroxyprogesterone), which belonged to the steroid biosynthesis pathway as significant metabolites upregulated by citrus juice intake. Additionally, these results confirmed the importance of using the non-targeted metabolomics technique to identify new endogenous metabolites, up- or down-regulated as a consequence of food intake. © 2012 Elsevier Ltd. All rights reserved. | Descripción: | et al. | URI: | http://hdl.handle.net/10261/73923 | DOI: | 10.1016/j.foodchem.2012.09.004 | Identificadores: | doi: 10.1016/j.foodchem.2012.09.004 issn: 0308-8146 |
| Aparece en las colecciones: | (CEBAS) Artículos (ICMA) Artículos |
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