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IGF-I expression is decreased in LIF-deficient mice after peripheral nerve injury

AuthorsPablo, Flora de ; Banner, Lisa R.; Patterson, Paul H.
knock out mice
sciatic nerve
Issue Date27-Apr-2000
PublisherLippincott Williams & Wilkins
CitationNeuroReport, 11 (6) : 1365-1368 (2000)
AbstractWe investigated the regulation of insulin-like growth factor I (IGF-I) expression after sciatic nerve crush using leukemia inhibitory factor (LIF)-deficient mice. One day post-crush, IGF-I mRNA levels were lower in the LIF-deficient mouse nerve than in the wild type nerve. IGF-I protein, analyzed by immunohistochemistry, was also decreased 1 day post-crush in LIF-deficient nerves relative to wild type nerves. By 3 days post-crush, IGF-I immunoreactivity was induced in Schwann cells to equivalent levels in both types of nerve. After crush, IGF-I expression was also found in mast cells, and these were initially decreased in the LIF-deficient mice. Thus, LIF appears to regulate IGF-I expression in the peripheral nerve basally and early in the regeneration response in vivo
Description4 páginas -- PAGS nros. 1365-1368
Appears in Collections:(CIB) Artículos
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