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Title

Naltrindole administration during the preweanling period and manipulation affect adrenocortical reactivity in young rats

AuthorsFernández, Beatriz; Antelo, M. Teresa; Guaza, Carmen ; Alberti Villanueva, Israel ; Pinillos, M. Luisa; Viveros, M. Paz
Issue Date1999
PublisherElsevier
CitationDevelopmental Brain Research 112: 135-137 (1999)
AbstractThe effect of a daily injection of the δ-selective opioid antagonist naltrindole (1 mg/kg), from birth to postnatal day 19, on basal and post- stress corticosterone levels in 25-day old rats of both sexes was investigated. The effects of manipulation were studied by including two control groups, one group received daily injections of saline and a second one was not manipulated. The stress protocol consisted of a 3 min swimming session in water at 20°C. Corticosterone determinations were performed by radioimmunoassay. Control non-manipulated animals showed a significant increase in corticosterone levels in response to stress. Manipulation decreased basal hormone levels in females and prevented the stress-induced rise in corticosterone in males. Functional blockade of the δ-receptor during the preweanling period by the naltrindole treatment inhibited the corticosterone response to stress in females. The results indicate the existence of sex differences in the effects of manipulation on hypothalamus- pituitary-adrenal axis activity and the involvement of the δ-opioid receptor in the modulation of the adrenocortical response to stress during the postnatal period.
URIhttp://hdl.handle.net/10261/73299
DOI10.1016/S0165-3806(98)00154-0
Identifiersdoi: 10.1016/S0165-3806(98)00154-0
issn: 0165-3806
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