Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/72743
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Microglia-derived nerve growth factor causes cell death in the developing retina |
Autor: | Frade López, José María CSIC ORCID ; Barde, Yves Alain | Fecha de publicación: | 1998 | Editor: | Cell Press | Citación: | Neuron 20: 35-41 (1998) | Resumen: | While nerve growth factor (NGF) is best known for its trophic functions, recent experiments indicate that it can also cause cell death during development by activating the neurotrophin receptor p75. We now identify microglial cells as the source of NGF as a killing agent in the developing eye. When the retina is separated from the surrounding tissue before colonization by microglial cells, no NGF can be detected, and cell death is dramatically reduced. It is restored by the addition of microglial cells, an effect that is blocked by NGF antibodies. NGF adsorbed at the surface of beads, but not soluble NGF, mimics the killing action of microglial cells. These results indicate an active role for macrophages in neuronal death. | URI: | http://hdl.handle.net/10261/72743 | Identificadores: | issn: 0896-6273 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
256
checked on 22-abr-2024
Download(s)
80
checked on 22-abr-2024
Google ScholarTM
Check
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.