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Título: | Beclin 1: A BH3-only protein that fails to induce apoptosis |
Autor: | Boya, Patricia CSIC ORCID ; Kroemer, Guido | Fecha de publicación: | 2009 | Editor: | Nature Publishing Group | Citación: | Oncogene, 28 : 2125-2127 (2009) | Resumen: | Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy. © 2009 Macmillan Publishers Limited. All rights reserved. | URI: | http://hdl.handle.net/10261/72510 | DOI: | 10.1038/onc.2009.83 | Identificadores: | doi: 10.1038/onc.2009.83 issn: 0950-9232 e-issn: 1476-5594 |
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