English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/72378
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Distinct regulation of cell cycle and survival in lymphocytes from patients with Alzheimer´s disease and amyotrophic lateral sclerosis

AuthorsBartolomé Robledo, Fernando ; Muñoz, Úrsula ; Esteras, Noemí ; Esteban, Jesús; Bermejo-Pareja, Félix; Martín-Requero, Ángeles
KeywordsAlzheimer’s disease
Amyotrophic lateral sclerosis
Cell proliferation
Issue Date1-Dec-2009
Publishere-Century Publishing
CitationInternational Journal of Clinical and Experimental Pathology 2(4) : 390-398 (2009)
AbstractAlterations in cell cycle progression seem to be associated with neuronal death in Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). We previously reported disturbances in the control of cell survival/death fate in immortalized lymphocytes from AD patients. These cell cycle dysfunction and impaired apoptosis were considered systemic manifestations of AD disease. The purpose of this study was to evaluate whether these abnormalities are characteristic of AD, or they may be seen in other neurodegenerative disorders such ALS. Our results indicate that alterations in signaling molecules, Akt and ERK1/2, and in the cyclin-dependent kinase complex inhibitors (CDKis) p21Cip1 and p27Kip1 are detectable in lymphoblasts from AD patients, but not in ALS patients, suggesting that these variables may be considered for the development of biomarkers of AD. However, lymphocytes from ALS patients do not represent a useful model to study cell cycle-related events associated with neurodegeneration of motoneurons
Description9 páginas, 6 figuras, 1 tabla -- PAGS nros. 390-398
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
ijcep 2009, 2 (390-398).pdf311,03 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.