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Role of estrogen receptor α in membrane-initiated signaling in neural cells: Interaction with IGF-1 receptor

AuthorsMarín, Raquel; Díaz, Mario; Alonso, Rafael; Sanz, Amaya; Arévalo, María Ángeles ; García-Segura, Luis M.
Issue Date2009
PublisherPergamon Press
CitationJournal of Steroid Biochemistry and Molecular Biology 114: 2-7 (2009)
AbstractThe mechanisms of action of estradiol in the nervous system involve nuclear-initiated steroid signaling and membrane-initiated steroid signaling. Estrogen receptors (ERs) are involved in both mechanisms. ERα interacts with the signaling of IGF-1 receptor in neural cells: ERα transcriptional activity is regulated by IGF-1 receptor signaling and estradiol regulates IGF-1 receptor signaling. The interaction between ERα and the IGF-1 receptor in the brain may occur at the plasma membrane of neurons and glial cells. Caveolin-1 may provide the scaffolding for the interaction of different membrane-associated molecules, including voltage-dependent anion channel, ERα and IGF-I receptor. © 2009 Elsevier Ltd. All rights reserved.
Identifiersdoi: 10.1016/j.jsbmb.2008.12.014
issn: 0960-0760
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