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MicroRNA precursors are not structurally robust but plastic

AuthorsRodrigo, Guillermo ; Elena, Santiago F.
KeywordsConformational flexibility
Non-coding rna
Secondary structure
Issue Date28-Dec-2012
PublisherOxford University Press
CitationGenome Biology and Evolution (2012)
AbstractRobustness is considered a ubiquitous property of living systems at all levels of organization, and small non-coding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication we question whether microRNA precursors (pre-miRNAs) are actually structurally robust, as previously suggested. We found that natural pre-miRNAs are not more robust than expected under an appropriate null model. On the contrary, we found that eukaryotic pre-miRNAs show a significant enrichment in conformational flexibility at the thermal equilibrium of the molecule, that is, in their plasticity. Our results further support the selection for functional diversification and evolvability in sncRNAs.
Publisher version (URL)http://doi.org/10.1093/gbe/evs132
Appears in Collections:(IBMCP) Artículos
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