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High expression of IL-13 receptor α2 in colorectal cancer is associated with invasion, liver metastasis and poor prognosis

AuthorsBarderas, Rodrigo ; Bartolomé, Rubén Álvaro ; Fernandez-Aceñero, M. Jesús; Torres, Sofía ; Casal, J. Ignacio
Issue Date1-Jun-2012
PublisherAmerican Association for Cancer Research
CitationCancer Research 72(11): 2780-2790 (2012)
AbstractAutocrine secretion of cytokines by metastatic colorectal cancer cells and their role during invasion and liver homing has been poorly characterized. In this study, we used cytokine arrays to analyze the secretomes of poorly and highly metastatic colorectal cancer cells. Compared with poorly metastatic cancer cells, highly metastatic cells expressed increased levels of the immunosuppressive cytokines IL-4 and IL-13 in addition to increased surface expression of the high affinity IL-13 receptor IL13Rα2, suggesting that IL13Rα2 mediates IL13 effects in colorectal cancer cells. Silencing of IL13Rα2 in highly metastatic cells led to a decrease in adhesion capacity in vitro and a reduction in liver homing and increased survival in vivo, revealing a role for this receptor in cell adhesion, migration, invasion and metastatic colonization. In support of this, IL-13 signaling activated the oncogenic signaling molecules PI3K, AKT, and SRC in highly metastatic cells. Clinically, high expression of IL13Rα2 was associated with later stages of disease progression and poor outcome in colorectal cancer patients. Our findings therefore support a critical role for IL13Rα2 expression in colon cancer invasion and metastasis
Description11 páginas, 6 figuras -- PAGS nros. 2780-2790
Publisher version (URL)http://dx.doi.org/10.1158/0008-5472.CAN-11-4090
Appears in Collections:(CIB) Artículos
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