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Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: Results of a phase I/II clinical trial

AuthorsPérez-Simón, José A.; López-Villar, Olga; Andreu, Enrique J.; Rifon, José; Muntión, Sandra; Campelo, María Díez; Sánchez-Guijo, Fermín M.; Martínez, Carmen ; Valcárcel, David; Cañizo, María Consuelo del
Issue Date2011
PublisherFerrata Storti Foundation
CitationHaematologica 96(7): 1072-1076 (2011)
AbstractThis trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human serum for the treatment of refractory acute or chronic graftversus- host disease. Twenty-eight expansions were started. In 22, a minimum of more than 1×106 mesenchymal stem cells/kg were obtained after a median of 26 days; this threshold was not obtained in the remaining cases. Ten patients received cells for the treatment of refractory or relapsed acute graft-versus-host disease and 8 for chronic disease. One patient treated for acute graft-versus-host disease obtained a complete response, 6 had a partial response and 3 did not respond. One of the chronic patients achieved complete remision, 3 a partial response, and 4 did not respond. The current study supports the use of this approach in less heavily treated patients for both acute and chronic graft-versus-host disease. The trial has been registered at ClinicalTrials.gov: identifier NCT00447460. © 2011 Ferrata Storti Foundation.
Identifiersdoi: 10.3324/haematol.2010.038356
issn: 0390-6078
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