Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/7048
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Adaptation and Response of Bifidobacterium animalis subsp. lactis to Bile: a Proteomic and Physiological Approach |
Autor: | Sánchez García, Borja CSIC ORCID; Champomier-Vergès, Marie-Christine; Stuer-Lauridsen, Birgitte; Ruas-Madiedo, Patricia CSIC ORCID ; Anglade, Patricia; Baraige, Fabienne; González de los Reyes-Gavilán, Clara CSIC ORCID ; Johansen, Eric; Zagorec, Monique; Margolles Barros, Abelardo CSIC ORCID | Palabras clave: | Bifidobacterias Bilis Probióticos |
Fecha de publicación: | 7-sep-2007 | Editor: | American Society for Microbiology | Citación: | Applied and Environmental Microbiology 73(21): 6757-6767 (2007) | Resumen: | Bile salts are natural detergents that facilitate the digestion and absorption of the hydrophobic components of the diet. However, their amphiphilic nature makes them very inhibitory for bacteria and strongly influences bacterial survival in the gastrointestinal tract. Adaptation to and tolerance of bile stress is therefore crucial for the persistence of bacteria in the human colonic niche. Bifidobacterium animalis subsp. lactis, a probiotic bacterium with documented health benefits, is applied largely in fermented dairy products. In this study, the effect of bile salts on proteomes of B. animalis subsp. lactis IPLA 4549 and its bile-resistant derivative B. animalis subsp. lactis 4549dOx was analyzed, leading to the identification of proteins which may represent the targets of bile salt response and adaptation in B. animalis subsp. lactis. The comparison of the wild-type and the bile-resistant strain responses allowed us to hypothesize about the resistance mechanisms acquired by the derivative resistant strain and about the bile salt response in B. animalis subsp. lactis. In addition, significant differences in the levels of metabolic end products of the bifid shunt and in the redox status of the cells were also detected, which correlate with some differences observed between the proteomes. These results indicate that adaptation and response to bile in B. animalis subsp. lactis involve several physiological mechanisms that are jointly dedicated to reduce the deleterious impact of bile on the cell's physiology. | URI: | http://hdl.handle.net/10261/7048 | DOI: | 10.1128/AEM.00637-07 | ISSN: | 0099-2240 |
Aparece en las colecciones: | (IPLA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Borja bilis 6757.pdf | 586,25 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
37
checked on 13-mar-2024
SCOPUSTM
Citations
116
checked on 14-mar-2024
WEB OF SCIENCETM
Citations
107
checked on 22-feb-2024
Page view(s)
478
checked on 18-mar-2024
Download(s)
285
checked on 18-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.