Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/69312COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC |
Autor: | Briales, Alejandra; Rodríguez-Martínez, José-Manuel CSIC ORCID; Velasco, Carmen; Díaz-de-Alba, Paula; Domínguez-Herrera, Juan; Pachón, Jerónimo CSIC ORCID; Pascual, Álvaro CSIC ORCID | Fecha de publicación: | 2011 | Editor: | American Society for Microbiology | Citación: | Antimicrobial Agents and Chemotherapy 55(3): 1266-1269 (2011) | Resumen: | This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution in GyrA, Ser80Arg substitution in ParC, and qnr gene expression increased the MIC of ciprofloxacin to 2 μg/ml. qnr genes present in E. coli that harbored a Ser83Leu substitution in GyrA increased mutant prevention concentration (MPC) values to 8 to 32 μg/ml. qnr gene expression in E. coli may play an important role in selecting for one-step FQ-resistant mutants. Copyright © 2011, American Society for Microbiology. All Rights Reserved. | URI: | http://hdl.handle.net/10261/69312 | DOI: | 10.1128/AAC.00927-10 | Identificadores: | doi: 10.1128/AAC.00927-10 issn: 0066-4804 |
| Aparece en las colecciones: | (IBIS) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
21
checked on 19-abr-2024
SCOPUSTM
Citations
49
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
46
checked on 27-feb-2024
Page view(s)
344
checked on 24-abr-2024
Download(s)
117
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.