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Título

M-Current suppression in PC12 cells by bradykinin is mediated by a pertussis toxin-insensitive G-protein and modulated by intracellular calcium

Autor Villarroel, Álvaro
Fecha de publicación 1996
EditorElsevier
Citación Brain Research 740: 227-233 (1996)
ResumenInhibition of the M-current in PC12 cells by bradykinin has been studied under whole-cell recording conditions. In cells dialyzed with GTP-γ-S, bradykinin produced a total and irreversible M-current suppression, while the inhibition was attenuated in cells dialyzed with GDP-β-S. Inhibition occurred in cells pretreated with pertussis toxin, while this treatment prevented the modulation of Ca2+ currents by muscarine. The rate and extent of inhibition increased with the level of intracellular Ca2+ from 0 to 70 nM. These results indicate that a pertussis toxin insensitive G-protein mediates the action of bradykinin on the M-current, and some steps in the second messenger cascade are modulated by Ca2+.
URI http://hdl.handle.net/10261/67589
DOI10.1016/S0006-8993(96)00870-0
Identificadoresdoi: 10.1016/S0006-8993(96)00870-0
issn: 0006-8993
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