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dc.contributor.authorGarzón, Javier-
dc.contributor.authorCastro, M. Ángeles-
dc.contributor.authorJuarros, J. L.-
dc.contributor.authorSánchez-Blázquez, Pilar-
dc.date.accessioned2013-02-27T12:11:35Z-
dc.date.available2013-02-27T12:11:35Z-
dc.date.issued1994-
dc.identifier.citationLife Sciences 54: 191- 196 (1994)-
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/10261/67489-
dc.description.abstractA polyclonal antiserum directed against the first 16 aminoacids of the N- terminal sequence of the murine δ opioid receptor was raised in rabbits. The intracerebroventricular (i.c.v.) injection to mice of the anti δ receptor IgGs impaired the antinociception produced by DPDPE, [D-Ala2]-Deltorphin II, DADLE and β-endorphin-(1-31) when studied 24 h later in the tail-flick test. Antinociception produced by morphine and DAMGO was fully expressed in mice undergoing this treatment. The selective δ antagonist ICI 174864 (0.8 nmols/mouse, i.c.v.) significantly reduced the antinociceptive activity of opioids to the extent observed after giving the antibodies. ICI 174864 did not decrease further the antinociception that remained after the anti δ receptor serum. The specific binding displayed by 3 nM [3H]-DPDPE was reduced in membranes pre-incubated with the antiserum, whereas no change could be detected for 0.6 nM [3H]-DAMGO labelling μ receptors. This experimental approach revealed the δ component of opioid-evoked supraspinal antinociception in mice.-
dc.language.isoeng-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.titleAntibodies raised against the N-terminal sequence of δ opioid receptors blocked δ-mediated supraspinal antinociception in mice-
dc.typeArtículo-
dc.identifier.doi10.1016/0024-3205(94)90167-8-
dc.date.updated2013-02-27T12:11:39Z-
dc.description.versionPeer Reviewed-
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