English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/67422
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1

AuthorsOcaña, Oscar H.; Córcoles, Rebeca; Fabra, Àngels; Moreno-Bueno, Gema ; Acloque, Hervé; Vega, Sonia; Barrallo-Gimeno, Alejandro; Cano, Amparo ; Nieto, M. Ángela
Issue Date2012
PublisherCell Press
CitationCancer Cell 22(6): 709-724 (2012)
AbstractThe epithelial-mesenchymal transition (EMT) is required in the embryo for the formation of tissues for which cells originate far from their final destination. Carcinoma cells hijack this program for tumor dissemination. The relevance of the EMT in cancer is still debated because it is unclear how these migratory cells colonize distant tissues to form macrometastases. We show that the homeobox factor Prrx1 is an EMT inducer conferring migratory and invasive properties. The loss of Prrx1 is required for cancer cells to metastasize in vivo, which revert to the epithelial phenotype concomitant with the acquisition of stem cell properties. Thus, unlike the classical EMT transcription factors, Prrx1 uncouples EMT and stemness, and is a biomarker associated with patient survival and lack of metastasis. © 2012 Elsevier Inc.
URIhttp://hdl.handle.net/10261/67422
DOI10.1016/j.ccr.2012.10.012
Identifiersdoi: 10.1016/j.ccr.2012.10.012
issn: 1535-6108
e-issn: 1878-3686
Appears in Collections:(IN) Artículos
(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.