Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/67084
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | II. (α)N-acetyl human β-endorphin-(1-31) alleviates the morphine withdrawal syndrome in rodents: A comparative study with clonidine |
Autor: | Garzón, Javier CSIC ORCID ; Sánchez-Blázquez, Pilar CSIC ORCID | Fecha de publicación: | 1992 | Editor: | Elsevier | Citación: | Life Sciences 50: 2099- 2109 (1992) | Resumen: | The potential effect of intracerebroventricular (icv) (α)N-acetyl human β-endorphin-(1-31) on morphine dependence was examined in mice and rats. Animals were rendered tolerant-dependent by subcutaneous (sc) implantation of an oily suspension (10 ml/Kg mouse and 3 ml/Kg rat) containing 0.1 g/ml of morphine, After 72 h of chronic morphine, 1 mg/Kg sc naloxone precipitated in both species a withdrawal syndrome that was moderate in animals pretreated with the acetylated derivative of β-endorphin. Doses of 28 fmols/rat or 80 fmols/mouse (α)N-acetyl human β-endorphin-(1-31) reduced the number of animals presenting the jumping behaviour, as well as the number of jumps recorded. Moreover, less than half of the rats presented the other withdrawal signs evaluated: squeak on touch, diarrhoea, chattering, chewing, ptosis and body shakes. This activity could be observed when (α)N-acetyl human β-endorphin was injected 1 h to 24 h before naloxone; longer intervals resulted ina significant loss of this activity. The α2 agonist clonidine given icv at pmol-nmol doses decreased the incidence of morphine withdrawal syndrome. Combinations of these two substances generally did not produce any further enhancement of the effects of clonidine and (α)N-acetyl β-endorphin when used alone. Icv injections of the antagonist of α2-adrenoceptors yohimbine prevented both clonidine and (α)N-acetyl β-endorphin-(1-31) from reducing the jumping behaviour displayed by morphine-abstinent mice. It is suggested that (α)N-acetyl β-endorphin produces this alleviation of the morphine withdrawal syndrome by improving the efficiency of α2-mediated agonist effects after acting on a neural substrate that is distinct from the μ opioid receptor binding site. | URI: | http://hdl.handle.net/10261/67084 | DOI: | 10.1016/0024-3205(92)90576-B | Identificadores: | doi: 10.1016/0024-3205(92)90576-B issn: 0024-3205 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
10
checked on 11-abr-2024
WEB OF SCIENCETM
Citations
13
checked on 26-feb-2024
Page view(s)
244
checked on 18-abr-2024
Download(s)
91
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.