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Radamycin, a novel thiopeptide produced by streptomyces sp. RSP9. I. Taxonomy, fermentation, isolation and biological activities

AuthorsGonzález Holgado Gloria; Castro Rodríguez, Julian; Díaz, Margarita ; Fernández-Ábalos, José M. ; Santamaría, Ramón I.
Issue Date2002
PublisherJapan Antibiotics Research Association
CitationJournal of Antibiotics 55(4): 383-390 (2002)
AbstractThe newly isolated strain Streptomyces sp. RSP9 produces two thiopeptides; one of them is methylsulfomycin I, which shows potent antibiotic activity against several gram-positive bacteria such as Micrococcus luteus and Staphylococcus aureus. The other is a new thiopeptide named radamycin. In the present work, this compound was purified and tested against several microorganisms and no antibiotic activity was detected in the assays. However, it does have a very strong capacity as an inducer of the tipA promoter, and indeed is the first reported molecule with tipA promoter induction capacity without detectable antibiotic activity. Induction of the tipA promoter also occurs with methylsulfomycin I.
DescriptionEl pdf del artículo es el manuscrito de autor.-- et al.
Publisher version (URL)http://dx.doi.org/10.7164/antibiotics.55.383
Identifiersdoi: 10.7164/antibiotics.55.383
issn: 0021-8820
e-issn: 1881-1469
Appears in Collections:(IMB) Artículos
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