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Título: | In Schizosaccharomyces pombe chs2p has no chitin synthase activity but is related to septum formation |
Autor: | Martín-García, Rebeca CSIC ORCID; Durán, Ángel CSIC; Valdivieso, María Henar CSIC ORCID | Fecha de publicación: | 2003 | Editor: | Elsevier | Citación: | FEBS Letters 549(1-3): 176-180 (2003) | Resumen: | Chitin synthesis occurs in most fungi through the action of different chitin synthase (CS) isoenzymes. In Schizosaccharomyces pombe the chs2+ gene codes for a protein with significant similarity to CS enzymes, but lacking most of the residues considered to be essential for activity, including the QRRRW domain. Here we show that chs2p is a functional protein that localises to the growing edge of the septum but is not a CS enzyme. Strong over-expression is lethal, while moderate expression leads to a severe defect in septum formation. These results suggest that chs2p has remained through evolution to play an alternative role in septation. © 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. | Descripción: | El pdf del artículo es la versión post-print. | Versión del editor: | http://dx.doi.org/10.1016/S0014-5793(03)00812-3 | URI: | http://hdl.handle.net/10261/66611 | DOI: | 10.1016/S0014-5793(03)00812-3 | Identificadores: | doi: 10.1016/S0014-5793(03)00812-3 issn: 0014-5793 |
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