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The class II tumor-suppressor gene RARRES-3 is expressed in B lymphoid leukemias and down regulated with disease progression

AuthorsCasanova, Benito; Fuente, María Teresa de la; Garcia-Gila, Mercedes; Sanz, Laura; Silva, Augusto ; García-Marco, José A.; García-Pardo, Angeles
B-chronic lymphocytic leukemia
mRNA differential display
tumor suppressor gene
lymphoproliferative disorders
Issue DateOct-2001
PublisherNature Publishing Group
CitationLeukemia 15(10):1521-1526(2001)
AbstractThe molecular pathogenesis of B cell chronic lymphocytic leukemia (B-CLL), the most common form of leukemia, remains unknown. We have used the mRNA differential display technique to analyze genes that may be involved in the development/progression of B-CLL. We have identified the tumor suppressor retinoic acid receptor responder 3 (RARRES3) as a B-CLL-related gene. RARRES3 maps to chromosome band 11q23, a region frequently deleted in lymphoproliferative disorders. To assess the potential involvement of RARRES3 in leukemogenesis, we examined 24 cases of B-CLL, 10 of acute lymphocytic leukemia (ALL) and five related cell lines by RT-PCR and sequence analyses. We report a correlation between RARRES3 down-regulation and B-CLL progression. We also found decreased RARRES3 gene levels in ALL cases and in the five cell lines studied. We did not find mutations in any of the leukemia samples assayed, including those with 11q23 deletion. These results indicate that RARRES3 may play a role in B-CLL progression. Leukemia (2001) 15, 1521-1526.
Description6 páginas, 2 figuras, 3 tablas -- PAGS nros. 1521-1526
Appears in Collections:(CIB) Artículos
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