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Title

Carrier and channel properties of mitochondrial transporters: Physiology and pathology?

AuthorsLedesma, Amalia ; Rial, Eduardo
KeywordsCarrier
Channel
fatty acid
mitochondria
permeability transition
Uncoupling
Issue DateJan-2004
PublisherInforma Healthcare
CitationToxicology Mechanisms and Methods, 14 (1-2) : 41-46 (2004)
AbstractThe mitochondrial metabolite transporters form a protein superfamily that is known to switch from its specific carrier mechanism to a channel/pore mode. The altered carrier function probably has pathophysiological significance. Thus, the permeability transition appears to be due to the switch of the adenine nucleotide translocator to a channel/pore mode. Similarly, when there exist abnormally high fatty-acid levels, mitochondrial carriers appear to mediate the fatty-acid uncoupling. It has been proposed that carriers facilitate the translocation of the fatty acid anion, although the possibility exists that the underlying mechanism is the conversion to the pore mode
Description6 páginas, 1 figura -- PAGS nros. 41-46
Publisher version (URL)http//dx.doi.org/10.1080/15376520490257437
URIhttp://hdl.handle.net/10261/66323
DOI10.1080/15376520490257437
ISSN1537-6516
E-ISSN1537-6524
Appears in Collections:(CIB) Artículos
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