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dc.contributor.authorGarcía-Gutiérrez, María Salud-
dc.contributor.authorGarcía-Bueno, Borja-
dc.contributor.authorZoppi, Silvia-
dc.contributor.authorLeza, Juan C.-
dc.contributor.authorManzanares, Jorge-
dc.date.accessioned2013-02-07T12:55:07Z-
dc.date.available2013-02-07T12:55:07Z-
dc.date.issued2012-
dc.identifierdoi: 10.1111/j.1476-5381.2011.01625.x-
dc.identifierissn: 0007-1188-
dc.identifiere-issn: 1476-5381-
dc.identifier.citationBritish Journal of Pharmacology 165(4): 951-964 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/66315-
dc.description.abstractBACKGROUND AND PURPOSE The aim of this study was to explore the effects of CB 2 receptor agonist and antagonist in the regulation of anxiety-like behaviours. EXPERIMENTAL APPROACHES Effects of acute and chronic treatment with the CB 2 receptor agonist JWH133 and CB 2 receptor antagonist AM630 were evaluated in the light-dark box (LDB) and elevated plus maze (EPM) tests in Swiss ICR mice. CB 2 receptor, GABA Aα 2 and GABA Aγ 2 gene and protein expression in the cortex and amygdala of mice chronically treated with JWH133 or AM630 were examined by RT-PCR and Western blot. Effects of chronic AM630 treatment were evaluated in spontaneously anxious DBA/2 mice in LDB. KEY RESULTS Acute JWH133 treatment failed to produce any effect. Acute AM630 treatment increased anxiety and was blocked by pre-treatment with JWH133. Chronic JWH133 treatment increased anxiety-like behaviour whereas chronic AM630 treatment was anxiolytic in LDB and EPM tests. Chronic AM630 treatment increased gene and reduced protein expression of CB 2 receptors, GABA Aα 2 and GABA Aγ 2 in cortex and amygdala. Chronic JWH133 treatment resulted in opposite gene and protein alterations. In addition, chronic AM630 administration decreased the anxiety of DBA/2 mice in the LDB test. CONCLUSIONS AND IMPLICATIONS The opposing behavioural and molecular changes observed after chronic treatment with AM630 or JWH133 support the key role of CB 2 receptors in the regulation of anxiety. Indeed, the efficacy of AM630 in reducing the anxiety of the spontaneously anxious DBA/2 strain of mice strengthens the potential of the CB 2 receptor as a new target in the treatment of anxiety-related disorders. © 2011 The British Pharmacological Society.-
dc.description.sponsorshipThis research was supported by grants from Ministry of Science and Innovation (SAF 2008-01106) and Ministry of Health (RETICS RD06/0001/1004, Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER and PNSD 2007/061) to JM. MSGG is a predoctoral fellow of the Ministry of Science and Innovation. AR is a technician supported by RETICS.-
dc.language.isoeng-
dc.publisherNature Publishing Group-
dc.rightsclosedAccess-
dc.titleChronic blockade of cannabinoid CB 2 receptors induces anxiolytic-like actions associated with alterations in GABA A receptors-
dc.typeartículo-
dc.identifier.doi10.1111/j.1476-5381.2011.01625.x-
dc.date.updated2013-02-07T12:55:07Z-
dc.description.versionPeer Reviewed-
dc.identifier.pmid21838753-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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