Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/66315
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | García-Gutiérrez, María Salud | - |
dc.contributor.author | García-Bueno, Borja | - |
dc.contributor.author | Zoppi, Silvia | - |
dc.contributor.author | Leza, Juan C. | - |
dc.contributor.author | Manzanares, Jorge | - |
dc.date.accessioned | 2013-02-07T12:55:07Z | - |
dc.date.available | 2013-02-07T12:55:07Z | - |
dc.date.issued | 2012 | - |
dc.identifier | doi: 10.1111/j.1476-5381.2011.01625.x | - |
dc.identifier | issn: 0007-1188 | - |
dc.identifier | e-issn: 1476-5381 | - |
dc.identifier.citation | British Journal of Pharmacology 165(4): 951-964 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/66315 | - |
dc.description.abstract | BACKGROUND AND PURPOSE The aim of this study was to explore the effects of CB 2 receptor agonist and antagonist in the regulation of anxiety-like behaviours. EXPERIMENTAL APPROACHES Effects of acute and chronic treatment with the CB 2 receptor agonist JWH133 and CB 2 receptor antagonist AM630 were evaluated in the light-dark box (LDB) and elevated plus maze (EPM) tests in Swiss ICR mice. CB 2 receptor, GABA Aα 2 and GABA Aγ 2 gene and protein expression in the cortex and amygdala of mice chronically treated with JWH133 or AM630 were examined by RT-PCR and Western blot. Effects of chronic AM630 treatment were evaluated in spontaneously anxious DBA/2 mice in LDB. KEY RESULTS Acute JWH133 treatment failed to produce any effect. Acute AM630 treatment increased anxiety and was blocked by pre-treatment with JWH133. Chronic JWH133 treatment increased anxiety-like behaviour whereas chronic AM630 treatment was anxiolytic in LDB and EPM tests. Chronic AM630 treatment increased gene and reduced protein expression of CB 2 receptors, GABA Aα 2 and GABA Aγ 2 in cortex and amygdala. Chronic JWH133 treatment resulted in opposite gene and protein alterations. In addition, chronic AM630 administration decreased the anxiety of DBA/2 mice in the LDB test. CONCLUSIONS AND IMPLICATIONS The opposing behavioural and molecular changes observed after chronic treatment with AM630 or JWH133 support the key role of CB 2 receptors in the regulation of anxiety. Indeed, the efficacy of AM630 in reducing the anxiety of the spontaneously anxious DBA/2 strain of mice strengthens the potential of the CB 2 receptor as a new target in the treatment of anxiety-related disorders. © 2011 The British Pharmacological Society. | - |
dc.description.sponsorship | This research was supported by grants from Ministry of Science and Innovation (SAF 2008-01106) and Ministry of Health (RETICS RD06/0001/1004, Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER and PNSD 2007/061) to JM. MSGG is a predoctoral fellow of the Ministry of Science and Innovation. AR is a technician supported by RETICS. | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | closedAccess | - |
dc.title | Chronic blockade of cannabinoid CB 2 receptors induces anxiolytic-like actions associated with alterations in GABA A receptors | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1111/j.1476-5381.2011.01625.x | - |
dc.date.updated | 2013-02-07T12:55:07Z | - |
dc.description.version | Peer Reviewed | - |
dc.identifier.pmid | 21838753 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
58
checked on 28-mar-2024
SCOPUSTM
Citations
107
checked on 27-mar-2024
WEB OF SCIENCETM
Citations
100
checked on 25-feb-2024
Page view(s)
300
checked on 27-mar-2024
Download(s)
82
checked on 27-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.