English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/65872
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus

AuthorsTeixeira, Catia M.; Kron, Michelle M.; Masachs, Nuria; Zhang, Helen; Lagace, Diane C.; Martínez, Albert; Reillo, Isabel; Duan, Xin; Bosch, Carles; Pujadas, Lluís; Brunso, Lucas; Song, Hongjun; Eisch, Amelia J.; Borrell, V.; Howell, Brian W.; Parent, Jack M.; Soriano, Eduardo
Issue Date2012
PublisherSociety for Neuroscience
CitationJournal of Neuroscience 32(35): 12051-12065 (2012)
AbstractAdult hippocampal neurogenesis is thought to be essential for learning and memory, and has been implicated in the pathogenesis of several disorders. Although recent studies have identified key factors regulating neuroprogenitor proliferation in the adult hippocampus, the mechanisms that control the migration and integration of adult-born neurons into circuits are largely unknown. Reelin is an extracellular matrix protein that is vital for neuronal development. Activation of the Reelin cascade leads to phosphorylation of Disabled-1, an adaptor protein required for Reelin signaling. Here we used transgenic mouse and retroviral reporters along with Reelin signaling gain-of-function and loss-of-function studies to show that the Reelin pathway regulates migration and dendritic development of adultgenerated hippocampal neurons. Whereas overexpression of Reelin accelerated dendritic maturation, inactivation of the Reelin signaling pathway specifically in adult neuroprogenitor cells resulted in aberrant migration, decreased dendrite development, formation of ectopic dendrites in the hilus, and the establishment of aberrant circuits. Our findings support a cell-autonomous and critical role for the Reelin pathway in regulating dendritic development and the integration of adult-generated granule cells and point to this pathway as a key regulator of adult neurogenesis. Moreover, our data reveal a novel role of the Reelin cascade in adult brain function with potential implications for the pathogenesis of several neurological and psychiatric disorders. © 2012 the authors.
URIhttp://hdl.handle.net/10261/65872
DOI10.1523/JNEUROSCI.1857-12.2012
Identifiersdoi: 10.1523/JNEUROSCI.1857-12.2012
issn: 0270-6474
e-issn: 1529-2401
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
Cell-Autonomous Inactivation.pdf5,86 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.