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Título

Protection and antibody response induced by intramuscular DNA vaccine encoding for viral haemorrhagic septicaemia virus (VHSV) G glycoprotein in turbot (Scophthalmus maximus)

AutorPereiro, Patricia CSIC ORCID; Martínez-López, Alicia CSIC ORCID; Falcó, Alberto; Dios, S. CSIC ORCID ; Figueras Huerta, Antonio ; Coll Morales, Julio; Novoa, Beatriz CSIC ORCID; Estepa, Amparo
Palabras claveDNA vaccine
VHSV
Turbot
Glycoprotein G
Rhabdovirus
Fecha de publicación2012
EditorElsevier
CitaciónFish and Shellfish Immunology 32(6): 1088-1096 (2012)
ResumenTurbot (Scophthalmus maximus) is a high-value farmed marine flatfish with growing demand and production levels in Europe susceptible to turbot-specific viral haemorrhagic septicaemia virus (VHSV) strains. To evaluate the possibility of controlling the outbreaks of this infectious disease by means of DNA vaccination, the gpG of a VHSV isolated from farmed turbot (VHSV860) was cloned into an expression plasmid containing the human cytomegalovirus (CMV) promoter (pMCV1.4-G860). In our experimental conditions, DNA immunised turbots were more than 85% protected against VHSV860 lethal challenge and showed both VHSV-gpG specific and neutralizing antibodies. To our knowledge this is the first report showing the efficacy of turbot genetic immunisation against a VHSV. Work is in progress to determine the contribution of innate and adaptive immunity to the protective response elicited by the immunization.
Descripción7 páginas, 5 figuras
Versión del editorhttp://dx.doi.org/10.1016/j.fsi.2012.03.004
URIhttp://hdl.handle.net/10261/64702
DOI10.1016/j.fsi.2012.03.004
ISSN1050-4648
E-ISSN1095-9947
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