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Título: | The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins |
Autor: | Domínguez, María CSIC ORCID; Vázquez, Jesús CSIC ORCID CVN; García-Navas, Rósula CSIC ORCID CVN; Mollinedo, Faustino CSIC ORCID | Fecha de publicación: | 2011 | Editor: | Wiley-VCH | Citación: | European Journal of Immunology 41(12): 3436-3442 (2011) | Resumen: | The P-selectin glycoprotein ligand-1 (PSGL-1) is involved in the initial contact of leukocytes with activated endothelium, and its adhesive function is regulated through its proteolytic processing. We have found that the metalloprotease ADAM8 is both associated with PSGL-1 through the ezrin-radixin-moesin actin-binding proteins and able to cause the proteolytic cleavage of this adhesion receptor. Accordingly, ADAM8 knockdown increases PSGL-1 expression, and functional assays show that ADAM8 is able to reduce leukocyte rolling on P-selectin and hence on activated endothelial cells. We conclude that ADAM8 modulates the expression and function of PSGL-1. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | URI: | http://hdl.handle.net/10261/63598 | DOI: | 10.1002/eji.201141764 | Identificadores: | doi: 10.1002/eji.201141764 issn: 0014-2980 e-issn: 1521-4141 |
Aparece en las colecciones: | (IBMCC) Artículos (CBM) Artículos |
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