English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/63544
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Microarchitectural changes during development of the cerebellar cortex

AuthorsMecha, Miriam ; Peña-Melián, A. L.; Blanco Fernández de Valderrama, María José
Issue Date2010
PublisherUniversidad del País Vasco
CitationInternational Journal of Developmental Biology 54: 691- 698 (2010)
AbstractThe cerebellum is a highly conserved structure in the Central Nervous System (CNS) of vertebrates, and is involved in the coordination of voluntary motor behaviour. Supporting this function, the cerebellar cortex presents a layered structure which requires a precise spatial and temporal coordination of proliferation, migration and differentiation events. One of the characteristics of the developing cortex is the formation of the external granule cell layer (EGL) in the outermost part. The EGL is a highly proliferative transient layer which disappears when cells migrate inwards to form the inner granule cell layer. The balance between proliferation and migration leads to changes in EGL thickness, and might be related to >indentations> observed in the surface of the developing chick cerebellum. We have extended the observation of this feature to quail and mouse, supporting the idea that this phenomenon forms part of the mechanisms of cerebellar morphogenesis. Different factors involved in both mitotic activity and migration were analyzed in this study. Our results indicate that proliferation, more than formation of raphes for cell migration, is involved in the formation of indentations in the EGL. In addition, we show that vessels penetrating from the pial surface divide the EGL into regular regions at the time of the appearance of bulges and furrows. We conclude that indentations are the result of a coincidence in time of both the increase in thickness of the EGL and the establishment of the embryonic vascular pattern, which confers a characteristic transitory morphology to the surface of folia. © 2009.
Identifiersdoi: 10.1387/ijdb.082670mm
issn: 0214-6282
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
Mecha,M.,2010,IntJDevBiol.,54,691-.pdf8,76 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.