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Cyclopropanation reactions for the synthesis of 2-azabieyclo[4.1.0]heptane derivatives with nitric oxide synthase inhibitory activity

AuthorsVillar, Irene S. del; Gradillas, Ana; Gómez-Ovalies, A.; Martínez-Murillo, Ricardo ; Martínez, Alfredo; Pérez-Castells, J.
Issue Date2008
PublisherChemical Society of Japan
CitationChemistry Letters 37: 1222- 1223 (2008)
AbstractSynthesis of new bicyclic structures containing cyclopro-panes, related to selective iNOS inhibitor ONO-1714, is described. We have evaluated the effect of the compounds obtained on the production of nitric oxide in lipopolysaccharide and inter-feron-gamma stimulated mouse peritoneal macrophages and on in vitro iNOS activity assays. Copyright © 2008 The Chemical Society of Japan.
Identifiersdoi: 10.1246/cl.2008.1222
issn: 0366-7022
Appears in Collections:(IC) Artículos
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