Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/63336
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Hippocampal Sclerosis: Histopathology Substrate and Magnetic Resonance Imaging

AutorPalacios Bote, R; Blázquez-Llorca, Lidia CSIC ORCID; Fernández-Gil, M. Á.; Alonso-Nanclares, Lidia CSIC ORCID CVN ; Muñoz Céspedes, Alberto CSIC ORCID; DeFelipe, Javier CSIC ORCID
Fecha de publicación2008
EditorW.B. Saunders
CitaciónSeminars in Ultrasound, CT and MRI 29: 2- 14 (2008)
ResumenThe term hippocampal sclerosis was originally used to describe a shrunken and hardened hippocampus, which histologically displayed neuronal loss and glial proliferation. These alterations are mainly located in the hilus of the dentate gyrus and in the CA1 and CA3 pyramidal cell layers but all hippocampal regions may show neuronal cell loss to varying degrees. A number of morphologic and cytochemical findings are associated with mesial temporal sclerosis, especially within the dentate gyrus. These changes include selective loss of inhibitory interneurons, abnormal sprouting of axons, reorganization of neural transmitter receptors, alterations in second messenger systems, and hyperexcitability of the granule cells. Extrahippocampal pathology is also found at other temporal lobe structures. Frequent extrahippocampal pathology affects the amygdala, first seen with neuronal cell loss and gliosis in the laterobasal complex. Surgical removal of this epileptogenic area can be curative or provide significant reduction in seizure frequency in the majority of individuals. Magnetic resonance imaging (MRI) is highly sensitive in detecting and locating mesial temporal sclerosis when a correct MRI temporal lobe protocol is used. The most important MRI findings, atrophy and abnormal T2 signal, allow us to detect mesial temporal sclerosis in the majority of the cases. Secondary MRI findings help in the diagnosis and lateralization of mesial temporal sclerosis in patients with subtle primary findings and in cases of bilateral hippocampal abnormalities. The development of advanced magnetic resonance (MR) techniques, such as functional MR, diffusion, or transference of magnetization, will lead to greater understanding of this pathology and will improve our diagnostic capacity. © 2008 Elsevier Inc. All rights reserved.
URIhttp://hdl.handle.net/10261/63336
DOI10.1053/j.sult.2007.11.005
Identificadoresdoi: 10.1053/j.sult.2007.11.005
issn: 0887-2171
Aparece en las colecciones: (IC) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

38
checked on 18-mar-2024

WEB OF SCIENCETM
Citations

33
checked on 28-feb-2024

Page view(s)

330
checked on 27-mar-2024

Download(s)

126
checked on 27-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.