Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/63177
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase |
Autor: | Manchado, Eusebio; Guillamot, María; García-Higuera, Irene CSIC ORCID; Moreno, Sergio CSIC ORCID; Cañamero, Marta; Malumbres, Marcos | Fecha de publicación: | 2010 | Editor: | Elsevier | Citación: | Cancer Cell 18(6): 641-654 (2010) | Resumen: | Targeting mitotic exit has been recently proposed as a relevant therapeutic approach against cancer. By using genetically engineered mice, we show that the APC/C cofactor Cdc20 is essential for anaphase onset in vivo in embryonic or adult cells, including progenitor/stem cells. Ablation of Cdc20 results in efficient regression of aggressive tumors, whereas current mitotic drugs display limited effects. Yet, Cdc20 null cells can exit from mitosis upon inactivation of Cdk1 and the kinase Mastl (Greatwall). This mitotic exit depends on the activity of PP2A phosphatase complexes containing B55α or B55δ regulatory subunits. These data illustrate the relevance of critical players of mitotic exit in mammals and their implications in the balance between cell death and mitotic exit in tumor cells. © 2010 Elsevier Inc. | URI: | http://hdl.handle.net/10261/63177 | DOI: | 10.1016/j.ccr.2010.10.028 | Identificadores: | doi: 10.1016/j.ccr.2010.10.028 issn: 1535-6108 e-issn: 1878-3686 |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
170
checked on 13-abr-2024
WEB OF SCIENCETM
Citations
168
checked on 21-feb-2024
Page view(s)
322
checked on 18-abr-2024
Download(s)
103
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.