English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/62645
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorCarlos, Juan A. de-
dc.contributor.authorLópez-Mascaraque, Laura-
dc.contributor.authorValverde, Facundo-
dc.date.accessioned2012-12-12T11:49:05Z-
dc.date.available2012-12-12T11:49:05Z-
dc.date.issued1996-
dc.identifierdoi: 10.1016/S0736-5748(96)00055-X-
dc.identifierissn: 0736-5748-
dc.identifier.citationInternational Journal of Developmental Neuroscience 14: 853- 866 (1996)-
dc.identifier.urihttp://hdl.handle.net/10261/62645-
dc.description.abstractThe formation and development of primary olfactory axons was studied in the rat embryo using acetylcholinesterase histochemistry, immunocytochemistry for neuron-specific β-tubulin (TuJ1) and growth associated protein 43 (GAP43), and a fluorescent tracer DiI. Olfactory axons extend from the olfactory receptor neurons localized in the olfactory epithelium. These fibers grow to reach and enter the olfactory bulbs, where they form the first relay and integrative synaptic station in the olfactory system: the olfactory glomerulus. In this communication we address the development of primary olfactory fibers: first from the olfactory placode and later from the olfactory epithelium. Olfactory fibers enter the olfactory bulbs apparently in a disordered manner but soon arrange themselves in hook shaped aggregates of fibers, with many boutons (inmature synaptic terminals), to form the glomeruli. We detected this kind of structure for the first time at embryonic day 16. The olfactory receptor cells are usually anchored in the basal lamina of the olfactory epithelium but some of them, after reaching their targets, lose their epithelial attachment, leave the olfactory epithelium and migrate to and enter the olfactory bulbs. The traffic of cells between tile olfactory epithelium and the brain lasts late into embryonic development. We describe four types of migratory mechanism used by different populations of cells to reach their targets in the telencephalic vesicle and propose the existence of migrating cells that enter the telencephalon. These data were corroborated by injections into the olfactory epithelium a of murine retrovirus carrying the Escherichia coli lac-Z gene.-
dc.language.isoeng-
dc.publisherPergamon Press-
dc.rightsclosedAccess-
dc.titleEarly olfactory fiber projections and cell migration into the rat telencephalon-
dc.typeartículo-
dc.identifier.doi10.1016/S0736-5748(96)00055-X-
dc.date.updated2012-12-12T11:49:05Z-
dc.description.versionPeer Reviewed-
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.