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dc.contributor.authorAbollo-Jiménez, Fernando-
dc.contributor.authorJiménez, Rafael-
dc.contributor.authorCobaleda, César-
dc.date.accessioned2012-12-12T10:37:32Z-
dc.date.available2012-12-12T10:37:32Z-
dc.date.issued2010-
dc.identifierdoi: 10.1016/j.semcancer.2010.02.002-
dc.identifierissn: 1044-579X-
dc.identifier.citationSeminars in Cancer Biology 20(2): 98-106 (2010)-
dc.identifier.urihttp://hdl.handle.net/10261/62594-
dc.description.abstractThe traditional approaches to cancer research and therapy have been primarily focused in the aspect of aberrant, uncontrolled, proliferation. Although this is clearly a very important issue, however, the emphasis on this characteristic has led to a relative neglect of an essential aspect of cancer biology: the alteration of normal differentiation processes. The oncogenic alterations that arise in an otherwise healthy cell lead to a whole reprogramming of the normal cellular fate and open a new pathologic developmental program. In this way cancer, reprogramming and cellular plasticity are tightly intertwined, since only some cells posses the necessary plasticity so as to allow the tumoral reprogramming to take place, and only some oncogenes have, in the right cellular context, the required tumoral reprogramming capacity. Research in the field of induced pluripotency is shedding a new light on the molecular mechanisms of tumor initiation and differentiation. In this review we discuss the latest findings in the area of cellular reprogramming and their implications from the point of view of tumor biology. © 2010 Elsevier Ltd.-
dc.description.sponsorshipResearch in the group is supported partially by FEDER (Fondo de Investigaciones Sanitarias PI080164), Proyectos Intramurales Especiales (CSIC), Fundación Mutua Madrileña and Junta de Castilla y León (SA060A09 and Proyecto Biomedicina 2009–2010). F.A.J. is the recipient of an FPU fellowship from Ministerio de Ciencia e Innovación.-
dc.language.isoeng-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.titlePhysiological cellular reprogramming and cancer-
dc.typeartículo-
dc.identifier.doi10.1016/j.semcancer.2010.02.002-
dc.date.updated2012-12-12T10:37:32Z-
dc.description.versionPeer Reviewed-
dc.contributor.funderFederación Española de Enfermedades Raras-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderFundación Mutua Madrileña-
dc.contributor.funderJunta de Castilla y León-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002924es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008061es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100014180es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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