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The Emerging Picture of Human Breast Cancer as a Stem Cell-based Disease

AuthorsCobaleda, César ; Cruz, Juan Jesús; González-Sarmiento, Rogelio ; Sánchez García, Isidro ; Pérez-Losada, J.
KeywordsMammary stem cell
Breast cancer
Cancer stem cells
Mouse models
Experimental Therapeutics
Translational Oncology
Issue Date2008
PublisherHumana Press
CitationStem Cell Reviews and Reports 4(2): 67-79 (2008)
AbstractThere are increasing data supporting the existence of a cell hierarchy within the mammary gland. At the top or this hierarchy a small population of cells with self-renewal properties maintains the tissue architecture and remodeling, and they are known as stem cells. Also, recent evidences indicate that breast cancer is originated and maintained by its own cancer stem cells reminding the normal mammary gland. The existence of this small population of cells with self-renewal capability has important biological and clinical significances. So, the interpretation of tumors as hierarchical cellular structures has changed our vision of the breast cancer scenario. Here, we review the current knowledge about normal and breast cancer stem cells, and their implications in cancer development, together with their consequences in breast cancer susceptibility, dissemination and treatment response.
Description13 páginas, 2 figuras.
Publisher version (URL)http://dx.doi.org/10.1007/s12015-008-9012-6
Appears in Collections:(IBMCC) Artículos
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