2,4-dichlorophenoxyacetic acid/partially methylated-β-cyclodextrin inclusion complexes

Abstract

In the present paper the complexation of 2,4-Dichlorophenoxyacetic acid (2,4-D) and a partially methylated-β-Cyclodextrin (PM-β-CD) has been studied in solution, being determined from the phase solubility diagram an apparent stability constant of 359.0 M-1 for the complex. Solid complexes were also obtained by different processing methods being investigated the inclusion process by scanning electron microscopy, infrared spectroscopy, differential scanning calorimetry, hot stage microscopy and x-ray diffractometry. Dissolution rate studies of the non-complexed and complexed pesticide were carried out. In all the cases the complex formation improved the dissolution rate. 2,4-D/PM-β-CD complexes may find use in pesticide formulations since they present important advantages.