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Título: | Whole-body periodic acceleration reduces brain damage in a focal ischemia model |
Autor: | Martínez-Murillo, Ricardo CSIC ORCID; Serrano, Julia CSIC ORCID CVN; Fernández Fernández, Ana Patricia CSIC; Martínez, Alfredo CSIC ORCID | Fecha de publicación: | 2009 | Editor: | Elsevier | Citación: | Neuroscience 158: 1390- 1396 (2009) | Resumen: | Stroke is the second most common cause of death and major cause of disability worldwide. Actual treatment involves surgery and/or thrombolytic drugs, but there is an urgent need for new approaches. Periodic acceleration, a rocking headward to footward movement of the whole body, is a non-invasive method to induce pulsatile shear stress on the vascular endothelium eliciting an enhanced production and secretion of endothelium-derived products such as nitric oxide, prostacyclin, prostaglandin E2, tissue plasminogen activator (tPA), and adrenomedullin. All these products have been shown to protect the brain from ischemic injuries. A rat model of focal brain ischemia was treated with application of periodic acceleration for 3 h immediately after the onset of ischemia. Controls remained static for the same period of time. Brain damage was assessed by magnetic resonance imaging (MRI) and biochemical markers. A significant reduction in brain damage was observed, 7 days post-ischemia, in rocked rats when compared with the static controls, through MRI. Furthermore, rocked animals had significantly lower levels of Beclin 1 and fractin than their static counterparts, and some isoforms of nitric oxide synthase were regulated by periodic acceleration. Our results show that periodic acceleration may provide a novel, affordable, non-invasive therapeutic option for the treatment of stroke. © 2009 IBRO. | URI: | http://hdl.handle.net/10261/62083 | DOI: | 10.1016/j.neuroscience.2008.12.005 | Identificadores: | doi: 10.1016/j.neuroscience.2008.12.005 issn: 0306-4522 |
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